Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates

Early Phase 1CompletedNCT03767361

Rania Ali El-Farrash65 enrolled

Overview

Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.

Oxidant-antioxidant status will be assessed by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as antioxidant minerals, in 65 term and near-term neonates.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

TRIPLE

Enrollment

Conditions

Blood Transfusion Complication Oxidative Stress

Interventions

packed red blood cells transfusionBIOLOGICAL

packed red blood cells transfusion

Eligibility

Sex: ALLMin age: 35 WeeksMax age: 37 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Premature neonates ≤36 weeks in need for blood transfusion. Exclusion Criteria: * Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies) * Extremely low birth weight neonates(\<1000gm birth weight ) * Recipient of blood transfusion before enrollment in the study. * Neonates planned for exchange transfusion .

Locations (1)

Rania Farrash

Cairo, Egypt