This single-center clinical study is being conducted over the course of 2 weeks to conduct an exploratory pilot study as a preliminary evaluation of D-OCT's ability to measure skin changes from aging. Assess structural differences between young and aged skin on the face. To identify the structural characteristics of atrophic acne scars relative to normal skin on the face. To explore characteristics of cellulite relative to normal skin on the thigh in young and aged skin.
Study Type
OBSERVATIONAL
Enrollment
99
Non-invasive in vivo skin imaging will be taken with the VivoSight D-OCT and the measurements will be acquired post-study utilizing VivoSight software.
Participants will be instructed to remove all makeup from the face and cleanse the face with SkinMedica Facial Cleanser at least 15 minutes prior to investigator assessments and photography, and at least 30 minutes prior to use of D-OCT. Particiapnts in the cellulite group will have the thigh area cleansed with Facial Cleanser at least 15 minutes prior to photography and at least 30 minutes prior to use of D-OCT. For standardization, this procedure will be performed with SkinMedica Facial Cleanser (to remove makeup and cleanse the face and thigh (if applicable)) for all the participants.
Skinmedica Clinical Research and Innovation Center
Irvine, California, United States
VivoSight software measurements of Epidermal Thickness
Epidermal thickness will be measured in microns.
Time frame: Day 1
VivoSight software measurements of surface roughness
Surface roughness measurements (Ra, Rq, Rz) will be measured in microns.
Time frame: Day 1
VivoSight software measurements of redness
Redness will be measured in percent
Time frame: Day 1
VivoSight software measurements of attenuation coefficient
Attenuation coefficient will be measured in AU (arbitrary unit)
Time frame: Day 1
Overall Photodamage Score at Day 1
The Investigator will assess the participant's overall photodamage using a 10-point scale where (0) = None to (9) = Severe).
Time frame: Day 1
Overall Appearance of Fine Lines/Wrinkles Cheek Areas
The investigator will assess the participant's appearance of fine lines/wrinkles using a 5-point scale from (0=None to 4=Diffuse).
Time frame: Day 1
Post-study Dynamic Optical Coherence Tomography (D-OCT) Image Analysis of Epidermal Thickness
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert.
Time frame: Day 1
Post-study D-OCT Image Analysis of Density and Attenuation Coefficient of Epidermis
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert.
Time frame: Day 1
Post-study D-OCT Image Analysis of Density and Attenuation Coefficient of Superficial Dermis
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert.
Time frame: Day 1
Post-study D-OCT Image Analysis of Collagen Fibers
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert. Measured as normal or in bundles.
Time frame: Day 1
Post-study D-OCT Image Analysis of Integrity of Collagen
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert. Measure as (few, moderate, or many fragments).
Time frame: Day 1
Post-study D-OCT Image Analysis of Score of Vessels
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert. Measured at 300 and 500 microns.
Time frame: Day 1
Post-study D-OCT Image Analysis of Vascularity Quantification with Thresholds
Post-study D-OCT image analysis will be done (at the sponsor's discretion) by an independent physician expert. Measured at 300 and 500 microns depth.
Time frame: Day 1
Blinded Independent Physician Assessor Grading of the D-OCT Images of Stratum Corneum Reflectivity
Grading (0 = absent to 3 = high).
Time frame: Day 1
Blinded Independent Physician Assessor Grading of the D-OCT images of Upper Dermal Reflectivity
Grading (0 = absent to 3 = high).
Time frame: Day 1
Blinded Independent Physician Assessor Grading of the D-OCT Images of Dermoepidermal Contrast
Grading (0 = absent to 3 = high).
Time frame: Day 1
Blinded Independent Physician Assessor Grading of the D-OCT images of Vessel Density
Grading (0 = no vessels to 3 = many vessels).
Time frame: Day 1
Antera 3D Images
The investigator will capture 3D images utilizing the Antera 3D.
Time frame: Day 1
VISIA-CR Images
The investigator will capture standardized digital photographs utilizing the VISIA-CR.
Time frame: Day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.