Genetic Analysis of Pediatric Psoriasis

Northwestern University86 enrolled

Overview

This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Psoriasis

Interventions

Saliva or buccal sampleOTHER

Saliva or buccal sample

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent. * Parents of patients who developed psoriasis before 12 years of age * Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated. Exclusion Criteria: * Patients, parents, and other family member unable to give a saliva or buccal swab sample. * Patients, parents, and other family member unable to give written informed consent.

Locations (1)

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

CARD14 mutations

The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort

Time frame: one year

Secondary Outcomes

De novo mutations

The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention.

Time frame: one year

Data from ClinicalTrials.gov

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