Cognition and MRI Markers in MS Patients With Aubagio® Treatment

Inclusion Criteria: PATIENTS * Male or female * Age 18-60 years * RRMS diagnosis according to McDonald criteria (Polman et al., 2005); * Treated with Aubagio® (Indication for first line therapy) * Native French speaking * Being affiliated to health insurance * Having signed an informed consent (at the latest on the day of inclusion and before any examination required by research) HEALTHY CONTROLS * Male or Female, * Age 18-60 years * Willing to participate and to sign informed consent. * Being affiliated to health insurance * Having signed an informed consent (at the latest on the day of inclusion and before any examination required by research) Exclusion Criteria: PATIENTS * History of neurological disease and/or other neurological diseases, * Psychiatric comorbidity including severe depression according to DSM-IV, * Alcohol or other addiction to toxic, * Disabling visual or motor problems preventing participation to neuropsychological assessments, * Acquisition disorders : Dyslexia, Dysphasia, Dyscalculia and dyspraxia, * Dosage change, stop or start of hypnotic or anxiolytic or antidepressive treatment less than 30 days * Relapse since less than one month, * Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily, * Prior neuropsychological testing with the same tests less than 6 months * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI * Illiteracy, is unable to count or to read * Pregnant or breastfeeding women * Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent) HEALTHY CONTROLS * History of neurological disease and/or neurological diseases * Psychiatric comorbidity including severe depression according to DSM-IV; * Alcohol or other toxic addiction; * Known cognitive complaint or neuropsychological affection * Hypnotic or anxiolytic or antidepressive treatment, * Prior neuropsychological testing with the same tests less than 6 months * Acquisition disorders: Dyslexia, Dysphasia, Dyscalculia and dyspraxia, * Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily, * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI * Illiteracy, is unable to count or to read * Pregnant or breastfeeding women * Person concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)