Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Universitätsklinikum Hamburg-Eppendorf83 enrolled

Overview

Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis Diastolic Dysfunction Lung Edema Fluid Overload

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis. Exclusion Criteria: * Patients with hemodynamically relevant cardiac defects. * Patients with mitral valve replacement. * Patients with pericardial effusion. * Patients with atrial fibrillation. * Patients with pacemaker therapy. * Patients with BMI \> 35 kg/m2. * Patients with poor examination conditions for ultrasound.

Outcomes

Primary Outcomes

Diastolic Dysfunction

Diastolic Dysfunction specified by echocardiographic doppler derived mitral inflow pattern and tissue doppler derived diastolic mitral annular velocities (E/E').

Time frame: While in septic condition, up to 10 days maximum.

Pulmonary Edema

Pulmonary edema specified by B line ultrasound score (Lung ultrasound protocol for the assessment of pulmonary fluid status according to Enghardt et al. 2015).