A Randomized Trial of a Biolimus-Coated Balloon Versus POBA in Small Vessel Coronary Artery Disease

General inclusion criteria 1. Subjects with stable angina pectoris, unstable angina pectoris, old myocardial infarction or silent myocardial ischemia with objective evidence; 2. Subjects at the age between ≥18 and ≤75 years old; 3. Subjects without contraindications of coronary revascularization (PCI or CABG); 4. Subjects are willing to participate in the study, sign informed consent form, and accept angiography follow-up at 9 months after operation as well as clinical follow-up after operation and at 30 days, 6 months, 9 months and 12 months after operation. Radiography inclusion criteria 1. Target lesion is primary in-situ coronary artery disease, located on 1 or 2 different coronary artery vessels, with no more than 1 target lesion on each coronary artery vessel (in case of lesion on two vessels, 2 target lesions are allowed at most); 2. Reference vessel diameter is between 2.0 mm and 2.75 mm (visual observation); 3. For non-target vessel lesion, interventional therapy needs to be conducted firstly (simultaneous therapy is required). After successful therapy, it is required to conduct random and target lesion treatment; 4. Preoperative diameter stenosis must be ≥70% or ≥50%, accompanied with corresponding ischemia of target vessel (visual observation); 5. Each target lesion of patients in test group and control group can only be treated with one trial device (Biolimus release coronary balloon catheter) or control device (Powerline balloon angioplasty catheter). Exclusion Criteria: General exclusion criteria 1. Any patient with myocardial infarction within one month; 2. Patients with severe congestive heart failure (NYHA Level IV severe heart failure) or severe valvular heart disease; 3. Patients with cardiogenic shock; 4. Patients with left ventricular ejection fraction of less than 35%; 5. Female patients planned for or in pregnancy (or lactation) or male patients planned for impregnation; 6. Patients with the expected lifetime of no more than 1 year or potential factors of difficulty in clinical follow-up; 7. Patients who are participating in the clinical trial of other drug or device without reaching the time limit of primary endpoint, or reaching the time limit of primary endpoint but less than 3 months; 8. Patients who plans to accept selective operation within 12 months; 9. Patients with severe liver failure (ALT and AST are larger than 3 times of the upper limit of normal value), who are judged to be not applicable to angiography by investigators; 10. Patients with severe renal failure(eGFR\<30ml/minute) or such medical history, failure to comply with angiography conditions; 11. Patients with stroke, peptic ulcer or gastrointestinal bleeding within the past 6 months; 12. Patients with bleeding tendency or coagulation disorders; 13. Patients who are intolerance to aspirin and/or clopidogrel or ticagrelor or have contraindications; 14. Subjects who are intolerance or allergic to heparin, contrast agent, Biolimus, polyethylene oxide and polylactic acid - glycolic acid polymer; 15. Patients with other diseases (for instance, malignant tumor, organ grafting or candidate) or addiction history (such as alcohol, cocaine and heroin); 16. Subjects who are considered to be not applicable to be enrolled by investigators due to other reasons. Radiography exclusion criteria 1. Evidence for extensive thrombus within target vessel; 2. Chronic total occlusion (TIMI Level 0 blood flow before operation); 3. For the left main disease and/or triple vessel disease and bypass lesion needed to be treated simultaneously, branch vessel diameter shall be ≥ 2.5mm bifurcation lesion; 4. Lesions within a distance of 3mm from circumflex branch, anterior descending branch and right coronary artery orifice; 5. After treating other vascular lesions at the same period, there are more than two lesions within the same target vessel needed to be treated; 6. There are more than 2 non-target lesions needed to be intervened or non-target lesion is not intervened before target lesion; 7. There is target vessel distortion or severe calcification lesion, so balloon catheter fails to pass it; 8. Target lesion is in-stent restenosis; 9. After predilation of target lesion, residual stenosis is ≥30% or TIMI blood flow is \< Level 3, and/or there is NHBL Level C or above dissection.