The study evaluates whether there is a reduction in the rate of postoperative progression of the disease following extensive mesenteric excision (EME), when compared to that of limited mesenteric excision (LME), in patients undergoing ileocolic resection for Crohn's disease. Half of participants will receive EME, while the other half will receive LME.
EME and LME are the two surgical procedures which are commonly used in the treatment of Crohn's disease. However, the areas of the mesenteric tissue resected are different. EME means that the mesentery is resected avoiding the root region, i.e. 1 cm from the root of ileocolic artery and vein. LME represents that the mesentery is retained, i.e. "Close shave" or 3 cm from the border of bowel (using whatever approach - clips, or haemostatic vessel sealing device).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
116
The mesentery is resected avoiding the root region.
The mesentery is retained.
General Hospital of Eastern Theater Command
Nanjing, Jiangsu, China
RECRUITINGAccumulated 5-year postoperative surgical recurrence
The requirement for repeat surgery for a Crohn's disease related indication.
Time frame: 5 years after the first surgery
Accumulated 5-year endoscopic recurrence
Disease proximal to the anastomosis or in the perianastomotic are considered to be a endoscopic recurrence (Rutgeert's score i2, or higher, disease in other sites is not considered recurrence)
Time frame: 5 years after the first surgery
Accumulated 5-year clinical recurrence
The presence of endoscopic disease (i2, or higher) or radiological evidence plus the presence of symptoms attributable to Crohn's disease that are severe enough to require medical or surgical treatment.
Time frame: 5 years after the first surgery
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