Laryngeal Adaptation for Speech and Swallowing

University of Florida

Overview

This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Stroke Spinocerebellar Ataxia Cerebral Stroke Dysphagia Dysarthria

Interventions

Intermittent Perturbation to Continuous PerturbationDEVICE

Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.

Continuous Perturbation to Intermittent PerturbationDEVICE

Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Patient Inclusion Criteria: All stroke and ataxia Ataxia * DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis * No recessive, X-linked or mitochondrial Stroke * Bilateral or unilateral middle cerebral artery (MCA) stroke * No structural abnormalities (i.e. nodules) * Dysphagia involving laryngeal dysfunction Stroke and ataxia with speech and swallowing disorders * no structural abnormalities * dysphagia involving laryngeal dysfunction Patient Exclusion Criteria: * Montreal Cognitive Assess. \<24 * Moderate to severe hearing loss * Barium allergy * Other confounding speech disorder (i.e. stuttering) * Chemo-radiation, surgical head and neck treatment * Smoking Hx in the past 5 yrs or \>5 years at any one time * Twenty one years of age or older * Breathing disorders or diseases

Outcomes

Primary Outcomes

Laryngeal Adaptation in Speech

To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading.

Time frame: Day 1

Laryngeal Adaptation in Swallowing

To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation.

Time frame: Day 1

Data from ClinicalTrials.gov

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