Gas Exchange Kinetics and Work Load During Exercise

University of California, Irvine94 enrolled

Overview

The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or treadmill. This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.

The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs. For example, some people like to exercise continuously for relatively long periods of time while others like to exercise for short periods of time with rest periods in between. Children tend to exercise in frequent bouts of brief exercise interspersed with periods of rest. Also, some people like running or treadmill exercise while others like to work out on stationary bicycles. To date, standard exercise testing is based on a century-old paradigm used predominantly for adults that involves maximal exercise protocols (cardiopulmonary exercise testing-CPET). Moreover, different but widely used exercise modalities such as cycle ergometer and treadmills are currently impossible to compare in children, and this has limited the clinical and research application of such testing in the pediatric age-range. A major premise of this laboratory is that laboratory testing of cardiopulmonary fitness in children should be based on protocols that mimic naturally occurring patterns of exercise in children, rather than those that have been artificially employed to assess maximal efforts in adults. This research project designed to begin the process of systematically identifying protocols can be best used for children and young adults. Participants will exercise in different protocols on a bicycle ergometer or treadmill. This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Methods of Exercise in Children

Interventions

Exercise TrainingOTHER

Comparison of stationary bike and treadmill exercise among children, adolescents and adults

Eligibility

Sex: ALLMin age: 7 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Between the ages of 7-35 years old without any known respiratory, cardiac or metabolic disease * Determined to be in good health by preparticipation history * No evidence of disease or disability that would impair participation in an exercise testing * No chronic prescribed medication Exclusion Criteria: * Other limitation which in the eyes of the physician that would preclude ability to perform exercise testing * Use of illegal drugs or abuse of alcohol * Pregnancy or breastfeeding

Locations (1)

Pediatric Exercise and Genomics Research Center, University of California, Irvine

Irvine, California, United States

Outcomes

Primary Outcomes

Maximum Oxygen Uptake (VO2) Measurements During Exercise

Breath by breath gas exchange VO2 in response to exercise.

Time frame: At least 48 hours

Secondary Outcomes

Heart Rate (HR) Measurements During Exercise

Heart Rate (HR) values in response to exercise

Time frame: At least 48 hours

Data from ClinicalTrials.gov

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