Observation on the Effect of Sacubitril/Valsartan in Advanced Chronic Kidney Disease（CKD）Patients With Heart Failure

Inclusion Criteria: 1. patients diagnosed with Chronic kidney disease (eGFR\<60 ml/ min/1.73m²) and heart failure 2. documented history of heart failure with associated signs or symptoms 3. New York Heart Association (NYHA) classes II-IV 4. mean sitting systolic blood pressure (msSBP) ⩾140mmHg 5. good compliance Exclusion Criteria: 1. isolated right heart failure owing to pulmonary disease, dyspnoea from non-cardiac causes, primary valvular or myocardial diseases, or coronary or cerebrovascular diseases needing revascularization within 3months of screening or during the trial 2. acute renal failure 3. systolic blood pressure lower than 100 mm Hg at screening (\<95 mm Hg at the randomisation visit) 4. significant laboratory abnormalities at screening interfering with assessment of study drug safety or efficacy(such as serum potassium\>5.5 or \<3.5mmol/L, serum sodium\<130mmol/L or alanine aminotransferase or aspartate aminotransferase\>2 times the upper limit of the normal range) 5. history of angioedema（drug-related or otherwise) 6. any medications that have potential for drug-drug interaction with LCZ696 will not be allowed during the study 7)pregnant female