Ibuprofen IV vs Acetaminophen IV for the Treatment of Pain Following Orthopaedic Low Extremity Surgery

Inclusion Criteria: * Scheduled for Orthopedic Low Extremity Surgery with general anesthesia and anticipated need post operative IV analgesia with anticipated use of \>48 hours. * Adequate IV access. * Anticipated hospital stay\>48 hours. * Age 18-70 years old with physical status ASA I- III. * Patients able to fill informed consent sheet. Exclusion Criteria: * patients with use of analgesia, muscle relaxants, NSAIDs and sedatives less than 24 hours to study drug administration * anemia (active, clinically significant anemia) and/or a history or evidence of asthma or heart failure * historical or at higher risk intracerebral bleeding, history of allergy or hypersensitive to NSAID, Ibuprofen, Acetaminophen or opioid * pregnant or nursing * body weight less than 30 kg * any active clinically significant bleeding or have underlying platelet dysfunction and/or receiving full dose anticoagulation therapy * GI bleeding that required medical intervention within the previous 6 weeks (unless definitive surgery has been performed) * on dialysis or renal dysfunction * impaired liver function * inability to achieve hemostasis or inability to close surgical incision prior to operating room discharge * operative procedure includes organ transplant, pre-and intra- operative procedure utilized for the prevention of pre- or post-operative pain (i.e, epidural or nerve blocks) * received anoher investigational drug within the past 30 days * known or suspected history of alcohol or drug abuse * severe infection and/or inflammatory disease