Virtual Prism Adaptation Therapy on Hemispatial Neglect

Seoul National University Hospital2 enrolled

Overview

The purpose of this study is to investigate the effect of virtual prism adaptation therapy on hemispatial neglect in chronic stroke patients. This study is the randomized, double-blind, sham-controlled, cross-over design. Total 10 patients will be allocated randomly to either real virtual prism adaptation therapy or sham therapy with the wash-out period of more than 2 weeks. Two sessions (20min/session) per day, for 5days (total 10 sessions) will be provided. Behavioral outcomes will be measured before and after completing a total of 10 sessions therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Stroke Recovery of Function Rehabilitation Perceptual Disorders Virtual Reality Exposure Therapy

Interventions

Virtual Prism Adaptation TherapyDEVICE

Hand trajectory will deviate to the right side in the virtual reality.

Sham TherapyDEVICE

The therapy is the same as the real virtual prism adaptation therapy, but there will be no deviation of the hand trajectory in the virtual reality.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 3 months after stroke onset * 2 or more tests indicative of hemispatial neglect in following 3 tests: 1)line bisection test, 2)Albert's test, 3)Drawing test. * Ability to recognize the target object, hand trajectory in the immersive virtual reality * 16 points or more in the Korean version of mini-mental state examination Exclusion Criteria: * Previous stroke or traumatic brain injury history * Can not cooperate during the therapy, due to delirium or aphasia * Unstable medical conditions * Severe psychiatric symptoms that interfere with the therapy participation (e.g. severe depression, agitation, psychotic symptoms) * Pregnancy * Can not maintain sitting posture

Locations (2)

Bundang Rusk Rehabilitation Specialty Hospital

Seongnam-si, Gyeonggi-do, South Korea

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Behavioral Inattention Test (BIT) Score

Range: 0(best) to 227(worst)

Time frame: Change from Baseline at 5 days

Secondary Outcomes

BIT Conventional subtest score (BITC)

Range: 0(best) to 146(worst)

Time frame: Change from Baseline at 5 days

BIT Behavioral subtest score (BITB)

Range: 0(best) to 81(worst)

Time frame: Change from Baseline at 5 days

Comb and Razor Test

Range: 0% deviation (best) to 100% deviation (worst)

Time frame: Change from Baseline at 5 days

Catherine Bergego Scale (CBS)

Range: 0 (best) to 30 (worst)

Time frame: Change from baseline at 5 days