Role of Wound Irrigation After Appendectomy

Mansoura University179 enrolled

Overview

Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection. The present trial aims to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution in prevention of superficial surgical site infection after open appendectomy for acute uncomplicated appendicitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

179

Conditions

Appendicitis

Interventions

IrrigationPROCEDURE

upon closure of the peritoneum gentamicin-saline solution (160 mg of gentamicin in 400 ml of normal saline 0.9%) will be used for irrigation of every layer of the wound before its closure

Eligibility

Sex: ALLMin age: 16 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients of both genders aging between 18 and 65 years who present with acute appendicitis. * Patients with perforated appendicitis will be also included. Exclusion Criteria: * Patients with appendicular mass, appendicular abscess, generalized peritonitis. * Patients with other causes of acute abdomen as revealed intraoperatively. * Patients taking long course of steroid therapy or immunosuppressive treatment, * Patients unwilling to participate in the trial.

Locations (1)

Mansoura university hospital

Al Mansurah, Dakahlia Governorate, Egypt

Outcomes

Primary Outcomes

Surgical site infection

The incidence of superficial site infection as detected by clinical examination on follow-up

Time frame: 2 months after surgery

Data from ClinicalTrials.gov

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