MRI Maker of Perioperative Neurocognitive Disorder

RenJi Hospital100 enrolled

Overview

Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Necrosis of Femoral Head Knee Osteoarthritis Fracture of Lower Limb

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 60 years * Spoke proficient Chinese * Selected to lower limb osteopathic surgery * Informed consent signed by the patient * Underwent general anesthesia Exclusion Criteria: * Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * With standard contraindications to MRI examinations * Unwillingness to comply with the protocol or procedures.

Locations (1)

Renji Hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

MRI markers of PND before 7th day after surgery

To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery

Time frame: From the day before surgery to the 7th day after surgery

Secondary Outcomes

MRI markers of PND before 12 month after surgery

To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 12 months after surgery

Time frame: From the 7th day after surgery to 12 month after surgery

Central Contacts

Diansan Su, Dr.

CONTACT

+862168383702 diansansu@yahoo.com

Data from ClinicalTrials.gov

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