This study aim to investigate the characteristics, complications and perinatal outcomes in pregnant women with placenta previa.
Placenta previa (PP) is defined as the placenta overlying the endocervical os and grades according to the relationship and the distance between the lower placental edge and the internal os of the uterine cervix: low-lying previa, marginal previa, partial previa, and complete previa. Cesarean delivery and assisted reproductive technology are associated with an increased risk of placenta previa in subsequent pregnancies. Other risk factors for previa include previous spontaneous, elective pregnancy terminations, previous uterine surgery, increasing maternal age and maternal parity, multiple gestations, smoking, cocaine use, and prior previa. It is associated with numerous adverse maternal and fetal-neonatal complications, such as perinatal hemorrhage, preterm birth, blood transfusion, hysterectomy, maternal intensive care unit admission, disseminated intravascular coagulation, septicemia, thrombophlebitis, and even fetal-neonatal and maternal death. This is a 1:2 prospective, matched and hospital-based case-control study to investigate the characteristics, complications and perinatal outcomes in pregnant women with placenta previa. For each placenta previa women, the investigators selected two none-placenta previa pregnant women as control from the same department matched on the mode of delivery, using simple random selection when excess matches are available. The date of their admission is limited to two days. This hospital is a tertiary university-affiliated medical center with a stable number of approximately 12,000 deliveries per year. Placenta previa is diagnosed by experienced ultrasonologists based on a transabdominal ultrasonic finding of placental tissue covering the internal cervical os before delivery, and further confirmed by obstetricians at delivery.
Study Type
OBSERVATIONAL
Enrollment
1,500
Maternal and Child Health Hospital of Foshan
Foshan, Guangdong, China
RECRUITINGNumber of Participants with postpartum hemorrhage
Blood loss \> 1000ml during cesarean section or \> 500 ml during vaginal delivery
Time frame: 24 hours after delivery
Number of Participants with antepartum hemorrhage
At least one episode of bleeding from the genital tract during the antenatal period
Time frame: From the time of viability of pregnancy to the delivery of the baby, assessed up to 42 weeks
Number of Participants with preterm birth
Before 37 completed gestational weeks
Time frame: From the time of viability of pregnancy to the delivery of the baby, assessed up to 37 weeks
Number of Participants with very preterm birth
Before 32 completed gestational weeks
Time frame: From the time of viability of pregnancy to the delivery of the baby, assessed up to 32 weeks
Number of participant needed for blood transfusion
Calculation of the number of participant needed for blood transfusion
Time frame: 72 hours after delivery
Number of urological injury
Calculation of the number of participant with bladder or ureteric injury
Time frame: 72 hours after delivery
Number of needed for extra surgical maneuvers
internal iliac ligation or hysterectomy
Time frame: 72 hours after delivery
Number of need for caesarean hysterectomy
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Yes or no
Time frame: 72 hours after delivery
Number of needed for neonatal ICU
Yes or no
Time frame: 72 hours after delivery
Number of needed for maternal ICU
Yes or no
Time frame: 72 hours after delivery