Chemical Peels and Fractional Laser on IGF-1 Levels in Skin

Inclusion Criteria: * Male and female subjects \>55 years old * Fitzpatrick type I-II * Able to provide informed consent. * Cutaneous photodamage of 3 or above on the Larnier photodamage scale (see Appendix). Exclusion Criteria: * Prior laser or peel treatment in the area evaluated in the current study in the past year. * Currently taking immunosuppressant medications known to interfere wound healing or anti-inflammatory medications (such as NSAIDs, or steroids). * Subjects who have underlying diseases that could alter wound healing response (such as Diabetes). * Currently taking insulin. * History of substance abuse, mental dysfunction, or other factors limiting ability to cooperate with study. * History of abnormal scarring such as Keloids. * History of vitiligo. * Allergy or sensitivity or allergy to topical anesthesia * Inability to use sunscreen. * History of smoking in the last 10 years * Scar or prior surgery in the area of treatment. * Use of isotretinoin in the prior 6 months * Subjects who have bleeding disorders or who are taking anticoagulants