Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development

University of Copenhagen16 enrolled

Overview

To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Insulin Resistance

Interventions

PlaceboDRUG

placebo tablet

NicorandilDRUG

20 mg nicorandil (Ikorel, Sanofi Winthrop Industrie; NIC)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non smokers * HbA1c \<38 mmol/mol (\<5.7%), HOMA-IR \> 1.7 (insulin resistant) * VO2max \<40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy) * BMI \>26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy) Exclusion Criteria: * Use of antidiabetic medication or any other medication deemed to interfere with study outcomes * Allergy towards Nicorandil * Chronic disease other than type 2 diabetes deemed to interfere with study outcomes * Excessive alcohol consumption (\>14 units/week) * Abnormal ECG

Locations (1)

University of Copenhagen

Copenhagen, Danmark, Denmark

Outcomes

Primary Outcomes

Extracellular potassium concentration meassured with microdialysis

Interstitial potassium

Time frame: Changes in potassium handling from the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks

Secondary Outcomes

Performance (time to exhaustion) during knee extensor exercise

Muscle exercise tolerance

Time frame: Changes in performance during the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks.

Data from ClinicalTrials.gov

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