Purpose to evaluate the effects of topical tranexamic acid (TA) on reducing post-partum hemorrhage in pregnant women with hemorrhagic cesarean section
Uterine atony is the major cause of postpartum hemorrhage (PPH), accounting for up to 80% of PPH cases. PPH is the leading cause of maternal morbidity and mortality worldwide, resulting in up to 28% of maternal deaths. Therefore, inducing a rapid and effective uterine contraction following delivery is an important issue. The aim of the study is to To explore the efficacy and safety of temporary uterine packing combined with topical tranexamic acid (TA) as an adjunct for reducing blood loss during a hemorrhagic cesarean delivery (CD), compared with placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
180
temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid
2 placebo ampoules to TA in 100 ml saline by slow infusion
Aswan University
Aswān, Egypt
number of patients need of additional pharmacological uterotonic
calculation number of patients need of additional pharmacological uterotonic
Time frame: 24 hours post operative
estimation of intraoperative blood loss (ml)
measure Intraoperative blood loss in ml by gravimetric methods
Time frame: during the operation
amount of postoperative blood loss
measure amount of blood loss post operative in ml by gravimetric methods
Time frame: 4 hours postoperative
number of patient with postpartum hemorrhage
calculation of the number of the patients with blood loss \>1000 ml
Time frame: 24 hours post operative
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