Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein thrombosis (CVT), retinal vein thrombosis, ovarian vein thrombosis, and renal vein thrombosis. The use of the novel direct oral anticoagulants (DOAC), thrombin or factor Xa-inhibitors (such as dabigatran, apixaban, edoxaban, rivaroxaban), in patients with unusual VTE in clinical practice is increasing. Through an international multicentre prospective registry, the investigators aim to evaluate the rationale for the use of the DOAC for the treatment of unusual site VTE and to assess the safety and effectiveness of this approach in real life clinical practice.
Study Type
OBSERVATIONAL
Enrollment
358
Consecutive adult patients with objectively diagnosed unusual site venous thrombosis and treated with one of the DOAC (e.g. apixaban, dabigatran, edoxaban, rivaroxaban) will be eligible for this observational prospective registry
Henry Ford Health System
Detroit, Michigan, United States
Ottawa Hospital Research Institute
Ottawa, Canada
CHU Amiens Picardie
Amiens, France
Hôpital de la Cavale Blanche
Brest, France
Hôpital Edouard Herriot
Lyon, France
Hopital Louis Mourier
Paris, France
Hôpital Européen Georges Pompidou
Paris, France
Centre Hospitalier Universitaire de Saint-Etienne
Saint-Etienne, France
Sheba medical center
Tel Litwinsky, Israel
Azienda Ospedaliera Universitaria di Bologna
Bologna, Italy
...and 14 more locations
Rationale for the use of the direct oral anticoagulants
Possible reasons for choosing one of the direct oral anticoagulant (multiple choice question)
Time frame: Baseline
Rate of major bleeding events
Time frame: 12 months
Rate of vascular events
Time frame: 12 months
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