The cumulus-corona-oocyte complex (COCs) surrounds each oocyte and must be removed prior to intracytoplasmic sperm injection (ICSI). This is traditionally achieved with a bovine-derived hyaluronidase followed by mechanical denudation through pipetting. A human recombinant hyaluronidase (Cumulase) has been developed to circumvent the problems and concerns associated with the animal origin and lack of purity of the bovine-derived form of the enzyme. whether cumulase offers a higher chance for success after ICSI for women with 8 COCs or lower remains an open question.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
586
Testing the effect of cumulase for women with poor oocyte yield due to poor ovarian reserve
Qena Fertility Center
Qina, Qena Governorate, Egypt
Banon Assiut
Asyut, Egypt
IbnSina IVF Center
Sohag, Egypt
Ongoing pregnancy rate
Continued pregnancy after 12 weeks of gestation
Time frame: 16 weeks
Biochemical pregnancy
Positive b-hCG at two weeks or more after embryo transfer
Time frame: Two weeks
Clinical pregnancy rate
Detection of gestational sac with a heartbeat on ultrasound at 7 weeks of gestation
Time frame: 7 weeks
Embryo developmental rate
fertilized oocytes per injected oocytes and developed embryos per fertilized oocytes
Time frame: 6 days of culture
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