Intradermal LPS and Antibiotics

Inclusion Criteria: 1. Healthy male or female subjects, 18 to 45 years of age, inclusive. Healthy status is defined by absence of evidence of any active or chronic disease following a detailed medical and surgical history, a complete physical examination including vital signs, 12-lead ECG, hematology, blood chemistry, blood serology and urinalysis; 2. Body mass index (BMI) between 18 and 30 kg/m2, inclusive, and with a minimum weight of 50 kg; 3. Fitzpatrick skin type I-III (Caucasian); 4. Able and willing to give written informed consent and to comply with the study restrictions. 5. Able to work with the eDiary app. Exclusion Criteria: 1. Any disease associated with immune system impairment, including auto-immune diseases, HIV and transplantation patients; 2. Type 1 or type 2 diabetes mellitus; 3. Any vaccination within the last 3 months; 4. Family history of psoriasis; 5. History of pathological scar formation (keloid, hypertrophic scar); 6. Have any current and / or recurrent pathologically, clinical significant skin condition at the treatment area (i.e. atopic dermatitis); 7. Hypersensitivity for dermatological marker at screening; 8. Requirement of immunosuppressive or immunomodulatory medication within 30 days prior to enrollment or planned to use during the course of the study; 9. Excessive sun exposure or a tanning booth within 3 weeks of enrollment; 10. Participation in an investigational drug or device study within 3 months prior to screening or more than 4 times a year; 11. Loss or donation of blood over 500 mL within three months prior to screening. Or the donation of plasma within 14 days prior to screening; 12. Current smoker and/or regular user of other nicotine-containing products (e.g., patches); 13. History of or current drug or substance abuse considered significant by the PI (or medically qualified designee), including a positive urine drug screen.