Effect of Nebulized Lidocaine on Postoperative Sore Throat

Antalya Training and Research Hospital110 enrolled

Overview

The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.

Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization). At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

110

Conditions

Sore Throat

Interventions

SalineOTHER

Effect of saline on postoperative sore throat

LidocaineOTHER

Effect of nebulized lidocaine on postoperative sore throat

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing video-assisted thoracic surgery requiring double lumen tube endotracheal intubation for one-lung ventilation * American Society of Anesthesiologists class 1,2 and 3 * Ability to consent Exclusion Criteria: * patients \<18 years old * body mass index (BMI) \<20 or \>35 kg/m2 * Mallampati grade 3 or 4 * mouth opening \< 3 cm * preexisting hoarseness or sore throat * coagulopathy * patient with upper respiratory tract infection

Locations (1)

Antalya Training and Research Hospital

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Changes in the incidence of postoperative sore throat

Sore throat was assessed using a 0-100 mm visual analog scale (VAS), where a score of 0 represents no pain and a score of 100 reflects the worst pain imaginable.

Time frame: 24 hours

Secondary Outcomes

whether the hoarseness was present or not

Hoarseness was defined as a change in voice quality and it was assessed by the patients themselves. The change in voice quality at any time during the observation period was defined as "hoarseness was present".

Time frame: 24 hours

Intraoperative opioid consumption

Assessed in intraoperative period

Time frame: 60 minutes

Postoperative analgesic consumption

Assessed in postoperative period

Time frame: 24 hours

Changes in mean arterial pressure

Assessed every 5 minutes during the procedure

Time frame: 60 minutes

Changes in heart rate

Assessed every 5 minutes during the procedure

Time frame: 60 minutes

Data from ClinicalTrials.gov

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