HAIC Plus H101 vs HAIC Alone for Unresectable HCC at BCLC A-B

Inclusion Criteria: * The diagnosis of HCC * Patients must have at least one tumor lesion that can be accurately measured according to mRECIST criteria. * With no previous treatment * Single lesion with tumor size larger 7cm or multiple lesions * No Cirrhosis or cirrhotic status of Child-Pugh class A only * Not amendable to surgical resection ,local ablative therapy and any other cured treatment. * BCLC A-B stage * The following laboratory parameters: Platelet count ≥ 50,000/μL Hemoglobin ≥ 8.5 g/dL Total bilirubin ≤ 30mmol/L Serum albumin ≥ 32 g/L ASL and AST ≤ 6 x upper limit of normal Serum creatinine ≤ 1.5 x upper limit of normal INR ≤ 1.5 or PT/APTT within normal limits Absolute neutrophil count (ANC) \>1,500/mm3 Exclusion Criteria: * Patients complicated by history of heart disease, history of gastrointestinal bleeding within 1 month, severe infection (\> grade 2 National Cancer Institute \[NCI\] -common Terminology Criteria for Adverse Events \[CTCAE\] version 4.0) or other serious associated diseases will not be able to tolerate treatment * With other malignant tumors * Known or suspected allergy to the investigational agents or any agent given in association with this trial * History of organ allograft * Pregnant or lactating woman * patients with poor compliance