A Validation Study of The Relationship Between ALDH2 and Aortic Dissection

N/AUnknownNCT03780738

Qilu Hospital of Shandong University200 enrolled

Overview

The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Aortic Dissection

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital Exclusion Criteria: * Aortic dissection based on trauma, connective tissue diseases and pregnancy * Patients with tumor * Patients with no written consensus

Locations (1)

Guangdong Provincial People's Hospital

Guanzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

Number of patients with different ALDH2 genotype

DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.

Time frame: 1-30 days after samples collected

Central Contacts

Xiao Li

CONTACT

+8618560088301 jfm3145496@163.com

Data from ClinicalTrials.gov

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