Multi-center Study to Transplant Hepatitis-C Infected Kidneys

Recipient Inclusion Criteria: * Estimated glomerular filtration rate(eGFR) \< 15 ml/min/1.73 m2 * Listed for an isolated kidney transplantation * Able to understand and adhere to the study visit schedule and all other protocol requirements, and must voluntarily sign and date an informed consent * No available medically acceptable, compatible living kidney donor * Subject must agree to use an effective method of birth control per protocol specifications Recipient Exclusion Criteria: * History of severe, life-threatening or other significant sensitivity to immunosuppressants utilized in kidney transplant * Female who is pregnant, breastfeeding, or is planning to become pregnant during the course of the study * History of HIV * HCV RNA positive * HBV surface Ag-positive or detectable HBV DNA * Primary focal segmental glomerulosclerosis (FSGS) or disease process with increased risk of causing early graft failure as assessed by the transplant nephrologist and/or investigator team * Presence of clinically significant liver disease * Transplant candidate requiring antibody desensitization protocol for transplantation * Most recent calculated panel reactive antibody (cPRA) \>80%. * Prior recipient of a non-renal solid organ transplant Donor Organ Inclusion Criteria * Deceased donor organ with kidney donor profile index (KDPI) ≤0.85 * HCV RNA-positive Donor Organ Exclusion Criteria * Known prior HCV treatment with direct acting antiviral medication * HIV RNA-positive * HBV Surface antigen-positive or HBV DNA-positive