Precise Percutaneous Coronary Intervention Plan (P3) Study

Inclusion Criteria: * Coronary artery disease in a major epicardial vessel with an invasive fractional flow reserve (FFR) ≤0.80 * An indication to Percutaneous coronary intervention Exclusion Criteria: \- Angiographic exclusion criteria 1. Severely calcified lesion/vessel 2. Bifurcation lesions. 3. Ostial lesions. 4. Left main disease. 5. Severe vessel tortuosity. Clinical exclusion criteria 1. Chronic obstructive pulmonary disease 2. Contraindication to adenosine 3. NYHA class III or IV, or last known left ventricular ejection fraction \<30% 4. Uncontrolled or recurrent ventricular tachycardia 5. Atrial fibrillation, flutter or arrhythmia 6. History of recent stroke (≤90 days) 7. History of acute coronary syndrome (≤90 days) 8. Prior myocardial infarction 9. History of ischemic stroke (\>90 days) with modified RANKIN score ≥ 2 10. History of any hemorrhagic stroke 11. Previous revascularization (PCI or Coronary artery bypass grafting) 12. Active liver disease or hepatic dysfunction, defined as AST or ALT \> 3 times the ULN 13. Severe renal dysfunction, defined as an eGFR \<30 mL/min/1.73 m2 14. Body mass index\>35 kg/m2 15. Nitrate intolerance 16. Contra-indication to heart rate lowering drugs Imaging-related 17. Insufficient coronary CT Angiography image quality.