The researchers in this trial want to analyze prerecorded patient data which provide information on benefits of the drug nifurtimox in patients with a sudden (acute) and long lasting (chronic) Chagas´ disease an illness caused by parasites mostly transmitted to humans by a bug. They also want to learn how often organs, especially the heart, are affected by the illness in treated and untreated chronic Chaga's patients. In order to find this out medical records of adult and pediatric patients in Argentina will be analyzed.
Study Type
OBSERVATIONAL
Enrollment
3,000
Nifurtimox is a drug already approved in some South American countries since more than 45 years
Many locations
Multiple Locations, Argentina
Parasitological cure of adult patients with chronic Chagas' disease
Change in the laboratory test result for Chagas' disease to negative after treatment with nifurtimox and without antitrypanosomal treatment compared to baseline. Adults are defined as patients who were 18 years or older at the time of initial diagnosis of acute or chronic Chagas' disease
Time frame: Retrospective analysis from late 1960s to about 1980
Parasitological cure of pediatric patients with acute and chronic Chagas' disease
Change in the laboratory test result for Chagas' disease to negative after treatment with nifurtimox and without antitrypanosomal treatment compared to baseline. Pediatric population will comprise patients aged 0 to below 18 years at the time of initial diagnosis of acute or chronic Chagas' disease
Time frame: Retrospective analysis from late 1960s to about 1980
Occurrence of cardiac manifestations in patients with chronic Chagas' disease
Change from a lower to a more advanced Kuschnir group or cardiac death (change of clinical group) and appearance of new abnormalities on ECG compared to baseline.
Time frame: Retrospective analysis from late 1960s to about 1980
Treatment of Cardiomyopathy and/or Heart Failure
Time frame: Retrospective analysis from late 1960s to about 1980
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