Targeted Radionuclide Therapy for Metastatic Melanoma [131I] ICF01012

Inclusion Criteria: * Patient with metastatic melanoma failure to recommended treatments by HAS. * Initial histological diagnosis of cutaneous melanoma pigmented or unknown status or choroidal melanoma. * Presence of at least one measurable lesion and / or evaluable in 18FDG-PET as PERCIST criteria. * Presence of at least one measurable lesion and / or evaluable as CT RECIST 1.1 criteria. * WHO performance index ≤ 2 . * Age\> 18 years * Life expectancy\> 3 months. * Creatinine ≤ 1,5 x ULN or creatinine clearance ≥ 60ml/min if creatinine \> 1,5 x ULN , Neutrophil \> 1,5.109L-1, Platellets \> 100 x 109L-1, prothrombine time \< 1,3 x control, Hemoglobin \> 9 g/dL, facteur V \> 80% (or AST, ALT ≤ 3 x LNS (≤ 5 x ULN if liver metastasis)). * Normal cardiac fonction (LVEF\> 40%). Exclusion Criteria: * Brain metastases symptomatic * Patient with a VI skin phototype * Previous treatment with chemotherapy, radiotherapy, immunotherapy and targeted therapy in the previous 4 weeks, the first injection of \[131I\] ICF01012 * Pregnant woman, nursing or woman of childbearing age refusing to follow effective contraception during treatment and 12 months after the administration of therapeutic dose. * Men refusing to follow effective contraception during treatment and 12 months after the administration of therapeutic dose * Other evolutionary known cancer in the past five years * Earlier irradiation of more than 25% of the bone marrow * Suspicion of invasion of more than 25% of the bone marrow on imaging 18F-FDG PET-CT * External Radiotherapy on target organs or the maximum dose as recommended in force * Uncontrolled diabetes * Known history of allergy to the excipients of the solution of \[131I\]ICF01012 * Any comorbidity or severe disease at the discretion of the investigator