It is a multi-center, open-label, observational study aimed to understand the pharmacokinetics and pharmacodynamics of the commonly used sedative, analgesic and antibiotic drugs in adult patients supported with extracorporeal membrane oxygenation (ECMO), by measuring the plasma concentrations and the clinical effect of dexmedetomidine, midazolam, butorphanol, remifentanil, sufentanil, propofol, linezolid, tigecycline, teicoplanin, caspofungin, voriconazole and meropenem.
Study Type
OBSERVATIONAL
Enrollment
36
The sedatives (dexmedetomidine, midazolam, propofol), analgesics (butorphanol, remifentanil, sufentanil), and six antibiotics (linezolid, voriconazole, tigecycline, teicoplanin, caspofungin and meropenem) will be used according to the clinical need.
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
RECRUITINGGuangzhou First People's Hospital
Guangzhou, Guangdong, China
RECRUITINGNanfang Hospital
Guangzhou, Guangdong, China
RECRUITINGMinimum Plasma Concentration [Cmin]
The minimum plasma concentration (the trough concentration), usually collected before the next dose.
Time frame: Up to 24 hours.
Area Under the Curve [AUC]
The area under the curve during the dose interval. It also can be calculated by the dose and the clearance of the drug.
Time frame: Up to 24 hours.
Maximum Plasma Concentration [Cmax]
The maximum plasma concentration, usually at the end of the infusion during an dose interval.
Time frame: Up to 24 hours.
ICU mortality
The intensive care unit (ICU) mortality is calculated as the number of deaths of the enrolled patients admitted to the ICU, divided by the number of the enrolled patient discharges from the ICU (including deaths and transfers), and often presented as percentage.
Time frame: Up to 60 days.
Hospital mortality
The hospital mortality is calculated as the number of deaths of the enrolled patients divided by the number of the total enrolled patient, and often presented as percentage.
Time frame: Up to 60 days.
Mechanical ventilation duration
Mechanical ventilation duration is the length of days the patients on the mechanical ventilation.
Time frame: Up to 60 days.
ICU length of stay (LOS)
ICU length of stay (LOS) is the length of days the patients in the ICU.
Time frame: Up to 60 days.
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