The human intestinal microbiota is composed of complex community of 10\*13 to 10\*14 commensal microorganisms\[1\]. Human intestine provides a nutrient-rich habitat for intestinal microorganism which allows a diverse ecosystem to enhance their host's immune system and facilitate digestive activities. Numerous researches are investigating the role of gut microbiota in human homeostasis, which may be related to the pathogenesis of gastrointestinal disease and autoimmune disorder. Fecal microbiota transplantation (FMT) is defined as infusion of feces from healthy donors to affected subjects. FMT works by altering the patient's microbiome and it is now recommended as an effective therapy for Clostridium difficile infection (CDI) not responding to standard therapies\[8\]. It has attracted great interest in recent years and many researches are exploring the FMT's potential role for treating other gastrointestinal disease such as IBD. A FMT registry is required to explore the relationship between disease prognosis and intestinal microbiota.
The human intestinal microbiota is composed of complex community of 10\*13 to 10\*14 commensal microorganisms\[1\]. Human intestine provides a nutrient-rich habitat for intestinal microorganism which allows a diverse ecosystem to enhance their host's immune system and facilitate digestive activities. Numerous researches are investigating the role of gut microbiota in human homeostasis, which may be related to the pathogenesis of gastrointestinal disease and autoimmune disorder. A research using gene-sequencing technique showed an abnormal microbiota composition such as specific group of Escherichia coli and decreased diversity of intestinal microbiota in individuals with Inflammatory Bowel Disease (IBD) \[2-4\]. These microbiotas may stimulate the production of cytokine and chemokines that leads to the mucosal inflammatory activity\[5\]. Gut microbiota may also link with the development of obesity and diabetes by affecting host fat storage and increasing energy harvest from the diet\[6-7\]. Fecal microbiota transplantation (FMT) is defined as infusion of feces from healthy donors to affected subjects. FMT works by altering the patient's microbiome and it is now recommended as an effective therapy for Clostridium difficile infection (CDI) not responding to standard therapies8. It has attracted great interest in recent years and many researches are exploring the FMT's potential role for treating other gastrointestinal disease such as IBD. A recent clinical study evaluated the efficacy of FMT in active Ulcerative Colitis. It showed one-forth cases of the FMT group were in UC remission and an increase in diversity of microbiota composition. However, these results were dependent on the donor\[9\]. There will be increasing use of FMT in clinical practice, as well as more studies investigating the effectiveness of FMT on other diseases in the future. However, as an emerging procedure, there is currently no registry system to track patient safety information of FMT. It is also equally important to promote scientific investigation around gut microbiome. Therefore, the investigators aim to establish a FMT registry platform to collect clinical data and specimen from FMT recipients and donors. This registry is initiated Hong Kong, and will be expanded to other part of Asia.
Study Type
OBSERVATIONAL
Enrollment
3,000
Prince of Wales Hospital
Hong Kong, Hong Kong
RECRUITINGSet up a FMT registry
Set up a registry of FMT to collect data such as demographics, past medical history, surgery, severity of disease indicated for FMT cases
Time frame: 10 years
Patient outcome of FMT
Compare the severity of disease, any adverse event related to FMT and hospitalization between baseline and FMT. Survey
Time frame: 10 years
Factors associated with successful FMT
Study samples will collected to characterize which microbiota favors FMT by performing metagenomics of gut microbiome in stool samples
Time frame: 10 years
Characterize FMT stool donors and other gut-related microbiota products
Collect study samples to characterize which microbiota favors FMT by metagenomics
Time frame: 10 years
FMT in Asia
Gather information such as the severity of disease, any adverse event related to FMT and hospitalization from other study sites in Asia. Survey
Time frame: 10 years
Promoting scientific investigation in FMT
Collect study samples to characterize which microbiota favors FMT by metagenomics
Time frame: 10 years
Future research studies
Number of patients who may be eligible for participation in future research studies by collecting their information demographics, past medical history, surgery, severity of disease
Time frame: 10 years
Developing Biobank of FMT
Collect and store of study samples from recipients and donors to characterize which microbiota favors FMT by metagenomics
Time frame: 10 years
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