Objectives. To develop a new treatment for amblyopia using a perceptual learning approach. Hypothesis to be tested. Our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia. Design and subjects. A total of 36 patients with amblyopia will be randomized allocated into two intervention groups: Group 1, perceptual learning therapy. Group 2, occlusion therapy. A control group comprising of 18 subjects with normal vision will be recruited for comparison. A battery of tests will be used to assess a range of visual functions before and after the treatment intervention. Study instruments. Grating acuity testing system Interventions. We have established a clinical protocol for acuity training. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to indicate the location of the stimulus. Participants will be required to undertake 20 one-hour sessions of training. Main outcome measures. Resolution acuity, visual acuity, contrast sensitivity function
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
54
The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.
Participants will be required to patch the good eye for 20 days, 1 hour per day.
Optometry Research Clinic
Hong Kong, Hong Kong
Change of grating acuity
Grating acuity tests the participants' ability to resolve fine details. This study measures the change of grating acuity after 20 hours of vision training.
Time frame: 20 hours
Change of visual acuity
Visual acuity tests the participants' ability to resolve letters.This study measures the change of visual acuity after 20 hours of vision training.
Time frame: 20 hours
Change of contrast sensitivity
Contrast sensitivity reflects the participants' sensitivity to identify low contrast visual stimuli. This study measures the change of contrast sensitivity after 20 hours of vision training.
Time frame: 20 hours
Change of stereopsis
Visual acuity tests the 3-D perception. This study measures the change of stereopsis after 20 hours of vision training.
Time frame: 20 hours
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