Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry

Xuanwu Hospital, Beijing500 enrolled

Overview

Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry (CoCCA) is a single-center observational registry of patients hospitalized for acute ischemic cerebrovascular disease (AICVD) with atherosclerotic changes in both cerebral and coronary arteries. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.

Atherosclerosis has exerted huge global burden as the common pathological process underlying ischemic heart disease and cerebrovascular disease. A substantial portion of acute ischemic cerebrovascular disease (AICVD) patients have both cerebral and coronary atherosclerosis, which is an omen of poor outcomes. But there is large evidence gap in these high-risk patients' prognosis-related factors, limiting the improvement of care quality. Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry (CoCCA) is a single-center prospective observational registry of patients hospitalized for AICVD with atherosclerotic changes in both cerebral and coronary arteries. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies. The clinical, imaging and laboratory information will be collected at the baseline. During an estimated 5-year follow-up, the vessel-related diagnostic or monitoring procedures, treatment, functional status and new vascular events will be recorded by web-based patients' self-reports, investigators' regular telephone visits.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Coexistence of Cerebral and Coronary Atherosclerosis Acute Ischemic Cerebrovascular Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosed as ischemic stroke or transient ischemic attack (TIA). 2. Less than 30 days after onset of ischemic stroke or TIA symptoms. 3. Extracranial or intracranial cerebral atherosclerosis confirmed by vascular ultrasound or CT angiograpgy or MR angiograpgy or digital substraction angiography. 4. Coronary atherosclerosis confirmed by CT angiograpgy or MR angiograpgy or digital substraction angiography; or with myocardial ischemia symptoms confirmed using electrocardiogram or echocardiography or cardiac MR; or with a history of percutaneous coronary intervention or coronary artery bypass graft. Exclusion Criteria: 1. With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 5 years. 2. Patients refuse to participate in the research.

Outcomes

Primary Outcomes

Rate of Major Adverse Cardiovascular Events

cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina

Time frame: 1 year

Secondary Outcomes

Rate of Major Adverse Cardiovascular Events

cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina

Time frame: 90 days

Functional Outcome

Percentage of patients with modified Rankin Scale (mRS) scores (minimum 0 and maximum 5) 3 to 5, who are considered to be disabled.

Time frame: 90 days

Rate of Ischemic Stroke

fatal and nonfatal ischemic stroke.

Time frame: 1 year

Rate of Acute Coronary Syndrome

fatal and nonfatal myocardial infarction and unstable angina

Time frame: 1 year

Rate of Cardiovascular Mortality

any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death

Time frame: 1 year

Time to First Major Adverse Cardiovascular Event

from the date of enrollment until the date of first documented cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction or unstable angina, whichever comes first, assessed up to 5 years

Time frame: 5 years

Time to First Ischemic Stroke

from the date of enrollment until the date of first documented ischemic stroke, assessed up to 5 years

Time frame: 5 years

Rate of Major Adverse Cardiovascular Events

cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina

Time frame: 5 years

Rate of Ischemic Stroke

fatal and nonfatal ischemic stroke

Time frame: 5 years

Rate of Acute Coronary Syndrome

fatal and nonfatal myocardial infarction and unstable angina

Time frame: 5 years

Rate of Cardiovascular Mortality

any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death

Time frame: 5 years

Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts