Evaluate the Transcatheter Artificial Aortic Valve and Transcatheter Artificial Heart Values Delivery System

Inclusion Criteria: * Subjects ≥ 65 years of age; * Severe aortic stenosis, as defined by ultrasonic cardiogram (peak velocity ≥4.0 m/s, or mean transaortic systolic pressure gradient ≥40 mmHg, or an aortic valve area of \<1.0 cm2) or combined merger; severe aortic insufficiency (regurgitation ≥+++ or regurgitation area ≥0.3cm2) combined with left ventricular dilatation ( LVESD≥50mm or LVEDD≥65mm);or severe aortic valve insufficiency combined with left ventricular systolic dysfunction (LVEF\<50%); * Symptoms suggestive of aortic stenosis, NYHA class III or IV; * Patients who are considered unsuitable for surgery are considered by two or more than two cardiovascular specialists (≥6% using Society of Thoracic Surgeons scoring system estimation; or there is a severe and irreversible organ damage to the patient, such as lung disease, liver disease, kidney disease and so on; or the patient's physical weakness can not be tolerated by surgery; or have other factors affecting surgery, such as postoperative chest radiosurgery, thoracic deformity, and diffuse severe calcification of the aorta, etc); * A life expectancy of \> 1 year; * Voluntarily participate in and sign the informed consent form and willing to undergo the related examination and clinical follow-up. Exclusion Criteria: * Untreated severe coronary stenosis and needs revascularization; or acute myocardial infarction occurred within 1 months, or coronary stent implantation in 1 month; * Artificial heart valve and artificial valve ring have been implanted； * Severe mitral insufficiency (regurgitation ≥+++) or mitral stenosis (valvular area\<1.5 cm2)； * left ventricular or atrial thrombus; * Aortic annulus diameter \<17mm or \>27 mm; * Severe left ventricular dysfunction, ejection fraction \<20%； * Severe pulmonary hypertension or severe right ventricular dysfunction； * The ascending aortic ≥5cm or Aortic root diameter ≥4.5cm; * Cerebrovascular event in last 3 months； * Active endocarditis or other active infection; * Severe renal failure and requires long-term dialysis treatment； * Severe liver dysfunction； * Active peptic ulcer； * Severe coagulation dysfunction; it is known that all anticoagulant schemes are taboo or allergic, or anticoagulants can not be used in the process of testing； * Severe respiratory failure； * Severe Alzheimer's disease； * Patients who were enrolled in any other study in one month; * Other cases which the researchers believe that it is not suitable to participate in.