Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization

Inclusion Criteria: * Participants included in this study will have the following criteria : ( 2 of 3 criteria ) 1. advanced maternal age or any other risk factor for POR : 1. Age ≥35 years 2. other risk factor of poor responder : ovarian surgery especially in case of endometrioma , chemotherapy, radiotherapy, autoimmune disorders, single ovary, chronic smoking, and unexplained Infertility. 2. previous poor ovarian response : Number of oocytes at the pickup time 3 or less . 3. Abnormal ovarian reserve tests : 1. FSH ≥12 mIu/ml in the early follicular phase . 2. Estradiol level more than 70 pg/dl in the early follicular phase 3. Anti-Mullerian hormone (AMH) below 0.5-1.1 ng/ml. 4. Antral follicle count (AFC) \< 5-7 follicles . Exclusion Criteria: 1. Age \>35 with good ovarian response . 2. any intra-uterine pathology can affect receptivity , ( for example ; Sub-mucosal fibroid , intra-uterine adhesions ). 3. Severe male factor infertility. 4. Extended endometriosis (stage 3 or more) . 5. All contraindications for estradiol : venous thrombo-embolism , stroke and breast cancer