Glucocorticoids are drugs that have many effects on body metabolism, raise sugar level in the blood, and reduce inflammation. By applying a statistical technique for combining the findings from a systematic literature review (meta analysis), researchers want to learn more about the relationship of the risk to develop a separation in the roof of the mouth (cleft palate) in newborns and contact with glucocorticoids during pregnancy.
Study Type
OBSERVATIONAL
Enrollment
99,999
Follow clinical administration
Many locations
Multiple Locations, Germany
Incidence of any type of orofacial cleft
Meta-analysis will be conducted with 18 observational studies. Oral clefts are defined as diagnosis of cleft lip with or without cleft palate or isolated cleft palate.
Time frame: Retrospective analysis from 1-Jan-1997 to 25-Jun-2018
Potency (mild, moderate, potent, very potent) of glucocorticosteroids
Potency of glucocorticoid * Mild * Moderate * Potent * Very potent
Time frame: Retrospective analysis from 1-Jan-1997 to 25-Jun-2018
Route of administration of glucocorticosteroids
Route of administration: * Topical * Systemic * Any other form of use
Time frame: Retrospective analysis from 1-Jan-1997 to 25-Jun-2018
Types of orofacial cleft
Types of orofacial cleft * Cleft lip (CP) * Cleft lip with or without palate (CLP) * Cleft palate (CP) * Orofacial cleft (OC)
Time frame: Retrospective analysis from 1-Jan-1997 to 25-Jun-2018
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