Kidney transplantation is the best available treatment option for patients with end stage renal disease. However, kidney transplantation requires life-long use of immunosuppressive medication. Because of the high cost of these medications we need to carefully evaluate the cost-effectiveness of each drug regimen, especially in low-middle income countries. The objective of this clinical trial is to compare the efficiency and cost of two immunosuppressive protocols after living donor kidney transplantation: (1) antithymocyte globulin, tacrolimus, azathioprine and prednisolone versus (2) basiliximab, tacrolimus, mycophenolate mofetil and prednisolone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
300
Induction agent for living donor kidney transplantation
Induction agent for living donor kidney transplantation
Doctor Salma Center for Kidney Diseases
Khartoum, Sudan
RECRUITINGIncidence of acute rejection
The incidence of acute rejection will include clinically diagnosed and biopsy proven acute rejection. Clinically diagnosed rejection includes at least 30% acute rise in serum creatinine level. Biopsy proven rejection will include both cellular and antibody mediated rejection according to Banff 2017 criteria
Time frame: 6 months post kidney transplant
One year graft survival
One year kidney allograft survival, uncensored for patient death
Time frame: 1 year post kidney transplant
Cost of immunosuppressive medication
Overall cost of immunosuppressive medication during first year post kidney transplant
Time frame: 1 year post kidney transplant+
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