Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension. Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
Study Type
OBSERVATIONAL
Enrollment
300
Aldosterone Renin Ratio to screen for Primary Aldosteronism
Changi General Hospital
Singapore, Singapore
Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
Time frame: 6 months
Accuracy of Screening test in early period post-stroke
To determine if the screening blood test for primary aldosteronism performed within 1 week post-stroke is equally accurate compared to being performed 2-4 months post-stroke.
Time frame: 3 months
Percentage of unilateral primary aldosteronism in patients admitted with acute stroke
Percentage of unilateral PA amongst patients with stroke
Time frame: 6 months
Percentage of patients with positive screening test in patients admitted with acute stroke
Time frame: 3 months
Blood pressure change after treatment for primary aldosteronism
Time frame: 12 months
Cardiac Complications
Cardiac complications in patients with primary aldosteronism, compared to those without primary aldosteronism, as assessed by transthoracic echocardiography features of left ventricular hypertrophy / mass, and diastolic dysfunction
Time frame: 6 months
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