This study is intended to observe the therapeutic effect of dydrogesterone on endometrial polyps and provide a reference for clinical treatment.
Endometrial polyps are a common female endometrial lesion.The long-term unrestrained exposure of estrogen to local tissue is one of the causes of polyp formation.Studies suggested that the progesterone can accelerate the regression rate of endometrial polyps due to its antiestrogenic effects.Based on this, investigators intended to observe the therapeutic effect of dydrogesterone on endometrial polyps and provide a reference for clinical treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
60
The investigators give participants oral dydrogesterone(as described in arm description).After 3 cycles of treatment, the investigators evaluate the treatment effects.
Peking Union Medical College Hospital
Beijing, China
Regression rate of endometrial polyps
No evidence of polyps or the maximum dimensions of polyps are reduced by 1/3 or more under pelvic ultrasound
Time frame: three months after the starting of treatment
Relapse rate of endometrial polyps
Evidence of polyps or the maximum dimensions of polyps are larger during the follow-up of the regression group after treatment
Time frame: six months after the starting of treatment
Side effects
Any side effects during the treatment
Time frame: three months after the starting of treatment
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