Multicenter Registry of Pediatric Lupus Nephritis in China

Inclusion Criteria: Diagnosis of lupus nephritis: * Diagnosis of SLE according to the 1997 update of the 1982 American College of Rheumatology revised criteria for classification of systemic lupus erythematosus * Either of the following: Positive urine protein detected 3 times within a week, or 24-hour urine protein\>150mg, or UPC\>0.2mg/mg, or urinary microalbumin above normal range detected 3 times within a week, or microscopic examination erythrocyte\>5 RBC/HP, or renal dysfunction including glomerular and/or tubular dyfunction, or abnormal renal biopsy and the pathological changes are in accordance with lupus nephritis * The pathological diagnosis of kidney conforms to the International Society of Nephrology and Society of Renal Pathology (ISN/RPS) standards in 2003 Exclusion Criteria (either of the following criteria): * Complicated with other systemic diseases, including basic diseases with clinical significance * Patients with tumors * Patients with abnormal glucose metabolism * Immunodeficiency patients * Patients diagnosed as tuberculosis, or hepatitis B, or hepatitis C within three months before treatment * Patients with other connective tissue diseases (such as Sjogren's syndrome, mixed connective tissue disease, etc.) * Drug-induced lupus, congenital lupus and other secondary lupus * Renal histopathology with non-inflammatory necrotizing angiopathy or thrombotic microangiopathy (TMA)