Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae

Inclusion Criteria: * Adults ≥ 18 years old * Adults ≤ 90 years old * Fistula or sinus tract opening size between 2 mm and 15 mm in diameter (as measured by comparing its size with the open mouth of a biopsy forceps) * Inpatient or outpatient setting * Recurrent or de novo fistulas or sinus tracts * A prior diagnosis of ADF OR ECF in which the standard therapy has failed or is not applicable * Fistula or sinus tract location may include: * Tracheopharyngeal * Tracheoesophageal * Bronchoesophageal * Gastric, duodenal, jejunal, ileal, colonic or anastomotic -communicating to the skin (cutaneous) * Esophogealgastric anastomosis * Mediastinal anastomotic leak * Fistula etiology may include: * Secondary to previous malignancy with complete remission * Secondary to radiotherapy as long as complete remission for 5 years has been achieved and documented * Congenital with or without previous treatment * Secondary to surgical interventions or endoscopic therapies such as dilation and esophageal manipulation * Post prolonged tracheal intubation * Secondary to inflammatory bowel disease * Secondary to foreign body ingestion * Secondary to thoracic trauma/crush injuries * Secondary to caustic ingestion * Secondary to pneumonectomy or mechanical ventilation * Esophagomalacia * The ability of subjects to give appropriate consent or have an appropriate representative available to do so * The ability of subjects to return for follow up endoscopic assessment as established. Exclusion Criteria * Exposure to any investigational drug or procedure within 3 months prior to study entry. * Patients with allergy to fibrin glue (TISSEEL) or anesthetics * Patients with active/ongoing malignancy such as esophageal, lung, tracheal, thyroid, oropharyngeal or gastric cancer * Patients on active regimen of chemotherapy * Patients receiving radiation * Diabetics with poor glucose metabolic control exhibited by an HbA1c \> 9 * If there is evidence, in endoscopy, of dysplastic-appearing mucosa such as Barrett's dysplasia near the fistula or sinus tracts, this will be excluded. Patients that require surgical intervention at the fistula or sinus tract area for any reason * BMI of \<16 (may difficult lipoaspiration procedure) * Women who are pregnant or nursing or women of childbearing potential who are unwilling to maintain contraceptive therapy for the duration of the study * Clinical signs of respiratory tract or pleuro-pulmonary infections * Prolonged (\> 6 months) use of steroids * Patients with fistulae or sinus tracts \>15mm * Drug or alcohol dependence * Active infectious disease positive for HIV, HTLV, HBV, HCV, CMV (IgM \> IgG) and/or syphilis * End of life