Open distal pancreatectomy (ODP) has been commonly employed for the treatment of a variety of cancers in body and tail of pancreas. Although many general surgical procedures have been increasingly performed laparoscopically or with laparoscopic assistance, until the current decade, laparoscopic pancreatic surgery had not been performed for its complicated anatomy. But laparoscopic distal pancreatectomy (LDP) has been widely accepted as a standard treatment for body and tail pancreatic cancer because there is no anastomosis in it, and LDP has gradually become the first choice for these cancers in clinical work. Although there are several studies about the comparison between LDP and ODP, most are retrospective and there is no agreement in surgical margin, lymph node numbers and prognosis to identify the oncological differences between the two surgical approaches. The investigators' pilot study showed that patients with body and tail pancreatic cancer underwent LDP had a better prognosis compared with the ones undergoing ODP, with no statistics differences in postoperative complications and mortality. This perspective RCT study is performed to confirm whether LDP would improve the prognosis for patients with body and tail pancreatic cancer compared with ODP.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
306
Laparoscopic distal pancreatectomy includes distal pancreatectomy, splenectomy, and regional lymph nodes resection for pancreatic cancer at the body and tail. Regional lymph nodes includes group 8, 10, 11, 18, 7, 9, 14, 15, according to the 2003 edition of lymph nodes group system defined by Japan Pancreas Society (JPS).
Open distal pancreatectomy includes distal pancreatectomy, splenectomy, and regional lymph nodes resection for pancreatic cancer at the body and tail. Regional lymph nodes includes group 8, 10, 11, 18, 7, 9, 14, 15, according to the 2003 edition of lymph nodes group system defined by Japan Pancreas Society (JPS).
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Hefei, Anhui, China
RECRUITINGDepartment of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
RECRUITINGDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University,
Harbin, Heilongjiang, China
RECRUITINGDepartment of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
RECRUITINGDepartment of Hepato-Pancreato-Biliary Surgery, The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
RECRUITINGDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Shanghai Pancreatic Cancer Institute; Pancreatic Cancer Institute, Fudan University. Shanghai, China
Shanghai, Shanghai Municipality, China
RECRUITINGShanghai Changzheng Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGWest China Hospital
Chengdu, Sichuan, China
RECRUITINGDepartment of Gastroenterology and Pancreatic Surgery, Zhejiang Provincial People's Hospital
Hanzhou, Zhejiang, China
RECRUITINGDepartment of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University
Harbin, China
RECRUITING...and 1 more locations
Recurrence Free Survival
RFS
Time frame: 2 years
Overall Survival
OS
Time frame: 2 years
R0 resection rate
R0 resection rate
Time frame: 2 years
Detected lymph node number
Detected lymph node number
Time frame: 2 years
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