Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects

Inclusion Criteria: 1. Male or female, non-smoker, ≥ 18 and ≤ 55 years of age, with BMI \> 18.5 and \< 30.0 kg/m2 and body weight ≥ 50.0 kg for males and ≥ 45.0 kg for females. 2. Healthy as defined by: 1. the absence of clinically significant illness and surgery within 4 weeks prior to dosing. 2. the absence of clinically significant history of neurological, endocrinal, cardiovascular, pulmonary, hematological, immunologic, psychiatric, gastrointestinal, renal, hepatic, and metabolic disease. 3. Females of childbearing potential must be willing to use acceptable contraceptive method throughout the study and for 30 days after the last study drug administration: 4. Male subjects must be willing to use acceptable contraceptive method from the first dosing until at least 90 days after the last study drug administration: 5. Male subjects (including men who have had vasectomies) with a pregnant partner must agree to use a condom from the first dosing until at least 90 days after the last study drug administration. 6. Male subjects must be willing not to donate sperm until 90 days following the last study drug administration. 7. Capable of consent. 8. Consent to perform genotyping for CYP2D6. Exclusion Criteria: 1. Any clinically significant abnormality at physical examination, clinically significant abnormal laboratory test results 2. Positive urine drug screen or urine cotinine test at screening. 3. History of allergic reactions to GC4419, DM, or other related drugs. 4. Use of any drugs known to induce or inhibit hepatic drug metabolism within 30 days prior to the first DM administration. 5. Poor CYP2D6 metabolizers as determined by genetic testing. 6. Positive pregnancy test at screening. 7. Any reason which, in the opinion of the Principal Investigator, would prevent the subject from participating in the study. 8. Clinically significant ECG abnormalities or vital sign abnormalities 9. History of significant alcohol abuse within one year prior to screening or regular use of alcohol within six months prior to the screening visit 10. History of significant drug abuse 11. Participation in a clinical research study involving the administration of an investigational or marketed drug or device within 30 days prior to the first dosing, administration of a biological product in the context of a clinical research study within 90 days prior to the first dosing, or concomitant participation in an investigational study involving no drug or device administration. 12. Use of medication other than hormonal contraceptives and topical products without significant systemic absorption: 13. Donation of plasma within 7 days prior to dosing. 14. Breast-feeding subject.