Repeatability and Reproducibility of the CADence™System

Inclusion Criteria: Subjects clinically indicated for nuclear stress test and who satisfy all the inclusion and exclusion criteria are eligible for participation. Inclusion criteria: 1. Age 22 years or older 2. Willing and able to give informed consent 3. Clinical indication for nuclear stress test evaluation 4. Chest pain syndrome 5. Two or more coronary artery disease risk factors as defined by: * Dyslipidemia: LDL \>130 mm/dL or HDL \<35 mm/dL or on treatment for dyslipidemia * Hypertension: blood pressure \>140 mmHg systolic, \>90 mmHg diastolic or on blood pressure altering treatment * Obesity: BMI\>28 * Current cigarette smoking * Diabetes: Type 1 or 2 * Family history: coronary disease in a first or second degree relative Exclusion Criteria: * Subjects clinically indicated for nuclear stress test and who satisfy all the inclusion and exclusion criteria are eligible for participation. Inclusion criteria: 1. Age 22 years or older 2. Willing and able to give informed consent 3. Clinical indication for nuclear stress test evaluation 4. Chest pain syndrome 5. Two or more coronary artery disease risk factors as defined by: * Dyslipidemia: LDL \>130 mm/dL or HDL \<35 mm/dL or on treatment for dyslipidemia * Hypertension: blood pressure \>140 mmHg systolic, \>90 mmHg diastolic or on blood pressure altering treatment * Obesity: BMI\>28 * Current cigarette smoking * Diabetes: Type 1 or 2 * Family history: coronary disease in a first or second degree relative Exclusion criteria: 1. Body Mass Index (BMI)\<18.5 or BMI \>40 2. Known coronary disease as defined as: * Prior bypass surgery or coronary stenting * Q-wave infarction on a past EKG (\>0.01 sec Q-wave duration in two adjacent leads) 3. Presence of pacemaker/defibrillator 4. Presence of artificial valve 5. Presence of obvious cyanotic or pre-diagnosed congenital heart defect and coarctation of the aorta 6. The presence of murmurs including moderate to severe valve disease, ventricular septal defects, and AV fistulae 7. Presence of moderate or severe valve disease as defined by \>1/6 heart murmur on physical diagnosis 8. Left Ventricular Assist Device (LVAD) 9. Presence of scars on the site thorax areas 10. Participation in trial within 30 days prior to collecting CADenceTM data except participation in registry studies 11. Asthma with wheezing 12. Inability to lie flat in the supine position 13. Acute coronary syndrome with elevated cardiac biomarkers (TP\>3x upper limit of normal (ULN) or CKMB\>3x ULN) 14. Heart transplant 15. Current cocaine use (within the past 24 hours, as reported by subject) 16. Chronic Obstructive Pulmonary Disease (COPD) 17. Patient is not an acceptable candidate for CT angiography: * Renal failure with GFR \<50 * Iodinated contrast allergy * Elevated heart rate which cannot be controlled sufficiently to achieve a good CT angiogram * Body weight \>350lbs * Persistent sinus rhythm abnormalities (e.g., atrial fibrillation) based on medical history.