The Application of Indocyanine-Green(ICG) Fluorescence Imaging in Hepatocellular Carcinoma

Zhujiang Hospital100 enrolled

Overview

This study aims to evaluate the feasibility of indocyanine green (ICG)-based fluorescence imaging in the detection of liver tumors. By correlating the ICG fluorescence patterns with pathologically confirmed tumors , it would be possible to use fluorescence navigation system in helping promoting oncology treatment.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Hepatocellular Carcinoma

Interventions

Indocyanine-Green(ICG)DRUG

ICG was administered intravenously 24 hours before the operation , or directly into the portal vein branches supplying the tumor-bearing hepatic segment, after puncturing of the target segments under intraoperative ultrasonography guidance.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years≤ Age ≤70 years * Compling with the diagnosis criteria of hepatic carcinoma. * Primary hepatic carcinoma without intrahepatic or extrahepatic extensive cancer metastasis, the metastatic hepatic carcinoma whose primary focal has been controlled. * Preoperative liver function is Child - Pugh grade A or B. * The patients are volunteered for the study. Exclusion Criteria: * Patients with mental illness. * Patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc. * The patients refused to take part in the study. * There are other co-existed malignant tumors. * Benign liver diseases. * Indocyanine green allergy

Locations (1)

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

The accuracy of detecting small liver tumor by ICG fluorescence.

The tumor which aggregate ICG fluorescence will be resected and dignosed by pathology. The accuracy of detecting small liver tumor by ICG fluorescence will be evaluated.

Time frame: 3 Days

The accuracy of positive margins of resection detected by ICG fluorescence.

The surgery margins will be detected by ICG fluorescence. If there is fluorescence aggregating, we consider the presence of residual tumor in the margin and proven by histological examination.

Time frame: 3 Days

Central Contacts

Chihua Fang, MD; PHD

CONTACT

+8613609700805 fangch_dr@126.com

Data from ClinicalTrials.gov

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