Assess impact of Tart Cherry Concentrate in cardiac surgical patients on POAF and related clinical and economic outcomes. Measure inflammation gene transcripts in cardiac tissue.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
50
Consume 2 servings (1 ounce or 2 tablespoon/serving) per day for three days before cardiac surgery
University of Michigan
Ann Arbor, Michigan, United States
Patient-reported tolerability score
Patients will complete a brief questionnaire regarding gastrointestinal status, using the Bristol Stool Form Scale
Time frame: One week
Efficacy as measured by total number of days in hospital within 60 days of surgery
Total number of days in hospital within 60 days of the index surgery
Time frame: 60 days
Efficacy as measured by altered (+/- 0.5 fold change) atrial transcript expression (mRNA) related to NFκB activation
Altered (+/- 0.5 fold change) atrial transcript expression (mRNA) related to NFκB activation
Time frame: 30 days
Time to conversion to normal sinus rhythm
Perioperative time to conversion to normal sinus rhythm
Time frame: 30 days
Heart rhythm at hospital discharge
Heart rhythm at hospital discharge
Time frame: 30 days
Heart rhythm at 30 days
Heart rhythm at 30 days
Time frame: 30 days
Need for permanent pacemaker within 30 days of surgery
Need for permanent pacemaker within 30 days of surgery
Time frame: 30 days
Cerebrovascular thromboembolism [stroke, TIA]
Incidences (yes/no, total number) of Cerebrovascular thromboembolism \[stroke, TIA\]
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Time frame: 30 days
Non-cerebrovascular thromboembolism
Incidences (yes/no, total number) of Non-cerebrovascular thromboembolism
Time frame: 30 days
Bleeding
Incidences (yes/no, total number) of Bleeding
Time frame: 30 days
Cerebrovascular events
Incidences (yes/no, total number) of Cerebrovascular events
Time frame: 30 days
Incidences of postoperative clinical events
Incidences (yes/no, total number) of Non-cerebrovascular events
Time frame: 30 days
Length of Hospital Stay
LOS \[Index hospitalization\]
Time frame: 60 days
Number of Re-hospitalization and ED visits
Number of Re-hospitalization and ED visits
Time frame: 60 days
Number of Outpatient Interventions
Number of Outpatient interventions
Time frame: 60 days
Total Costs for Hospital stay
Costs \[incident hospital stay\]
Time frame: 60 days