Hypothesis: Individuals presenting with prenatal alcohol exposure (PEA) show emotional abilities deficits, and imbalance between the two systems involved in decision-making according to dual-process models, namely an under-activated reflective system (involved in deliberate behaviors) and an over-activated affective-automatic one (involved in impulsive behaviors). Primary objective: To explore performance (as a percentage of correct answers) in an emotional facial expression decoding task in PEA participants compared to controls without alcohol disorder.
Each participant will undergo 2 visits : First visit : * Checking inclusion and non-inclusion criteria * Note of information and consent form * Record of concomitant treatments and anamnestic elements * Alcohol, Tobacco, and Toxic Consumption * Urinary Toxicity Test for Control Groups * Laterality test (Hecaen, 1984) * Brief visual and auditory acuity test * Standardized psychiatric interview (Mini International Neuropsychiatric Interview - MINI) Second visit = Experimental testing * State-Trait Anxiety Inventory, Beck Depression Inventory, Inventory of Interpersonal Problems, Toronto Alexithymia Scale (TAS-20). * Participant installation and testing: 6 behavioral tasks on a computer (also used to collect responses, except for task 2, see details below) : Task 1 (MAIN): Test for recognition of facial emotions Task 2: 'Reading the Mind in the Eyes Test' (Decoding of complex emotional states) Task 3: Emotional evaluation of natural scenes Task 4: Target detection (measure of attentional bias towards alcohol-related stimuli) Task 5: Go / No-Go evaluating the interactions between inhibition processes and auto-affective system Task 6: "N-back" evaluating the interactions between working memory and automatic-affective system
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
144
All tasks will be delivered using a laptop and E-Prime 2 software (Psychology Software Tools, Inc., Pittsburgh), which will also be used to collect behavioral responses.
CSAPA
Lille, France
CHRU Lille, Fontan2
Lille, France
Percentage of correct answers of an emotional facial expression (EFE)
Performance of an emotional facial expression (EFE) decoding task in EPA subjects and compare it to non-alcohol dependent controls
Time frame: one day
Psychopathological assessment by Mini International Neuropsychiatric Interview MINI
Presence of psychiatric disorders by a standardized psychiatric interview
Time frame: one day
Percentage of correct answers ant latency of behavioral answers
Performance of behavioral tasks
Time frame: one day
State-Trait-Anxiety Inventory (STAI) score
Score at STAI STAI is a psychological inventory based on a 4-point Likert scale and consists of 40 questions on a self-report basis
Time frame: one day
Beck Depression Inventory score
Score at Beck Depression Inventory The BDI consisted of twenty-one questions about how the subject has been feeling in the last week. Each question had a set of at least four possible responses, ranging in intensity. (0) I do not feel sad/ (1) I feel sad./ (2) I am sad all the time and I can't snap out of it/ (3) I am so sad or unhappy that I can't stand it. When the test is scored, a value of 0 to 3 is assigned for each answer and then the total score is compared to a key to determine the depression's severity. The standard cut-off scores were as follows:0-9: indicates minimal depression/ 10-18: indicates mild depression/ 19-29: indicates moderate depression/ 30-63: indicates severe depression.
Time frame: one day
Toronto Alexithymia Scale TAS-20 score
Score at TAS-20 The Toronto Alexithymia Scale is a measure of deficiency in understanding, processing, or describing emotions. The current version has twenty statements rated on a five-point Likert scale. ( range : Strongly disagree/Disagree/ Neither agree nor disagree/ Agree/ Strongly agree)
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Time frame: one day