Genetic Information as a Life Style Change Motivator

Natural Resources Institute Finland333 enrolled

Overview

The study investigates whether information on having a risk genotype (ApoE4) and life style advisory information affects lifestyle changes and sensory preferences. The project studies also the ethic aspects of giving the information of risk genotype.

We will run intervention based on our earlier pilot study. It includes intensive intervention and a modification of our earlier pilot intervention. Our intervention methods are general lectures of the effects of healthy diet (Finnish Nutrition Recommendations 2014) and healthy lifestyle for all participants. Effects on motivation, attitudes and preferences will be studied and verified by questionnaires and risk factors of cardiovascular disease and Alzheimer disease by analyzing clinical markers of lipid metabolism, general phenotype markers and profiles of nutritional markers. Nutritional biomarkers will verify also the self-reported changes of diet in the questionnaires and in digital food diaries.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

333

Conditions

Health Behavior Alzheimer Disease, Protection Against

Interventions

information on the risk gene statusBEHAVIORAL

information on risk gene status (APOE4 allele or not) was given before intervention

life style adviseBEHAVIORAL

all test persons were given information on healthy diet and life style

Eligibility

Sex: ALLMin age: 40 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 40 and 60 years * overall good health (no chronic conditions e.g. mental disorders, cancer, liver or kidney disease, current or previous diagnosis), * body mass index (BMI) under 35 kg/m2, * blood pressure under 140/90 mmHg (medication allowed), * serum total cholesterol under 7.25 mmol/l (medication allowed) * fasting plasma glucose level under 7 mmol/l. Exclusion Criteria: * Abnormal values of the alanine amino transferase, alkaline phosphatase, haptoglobin and thyroid stimulating hormone

Outcomes

Primary Outcomes

Number of participants with good quality of dietary fat

A questionnaire according to Finnish guidelines of Suomen Sydänliitto ry, Helldán \& Helakorpi, (2015)

Time frame: 2 years

Dietary habits, number of participants

A questionnaire asking for * Fish intake at least twice per week * Consumption of high fat and sugar foods * Consumption of vegetables * Alcohol consumption * Physical activity at least twice per week

Time frame: 2 years

Food choice questionnaire, health and taste attitude

Scale 1-7 (7 most important, fully agree)

Time frame: 2 years

Food involvement and Food mavenism, scale 1-5

5 fully agree

Time frame: 2 years

Health concern, scale 1-9

1 not concerned at all

Time frame: 2 years

Life-orientation test, scale 1-5

1 fully agree

Time frame: 2 years

Locus of Control, state-trait anxiety inventory, Three-Factor Eating Questionnaire (TFEQ) scale 1-4

4 fully agree

Time frame: 2 years

weight kg

Time frame: 2 years

height m

Time frame: 2 years

Waist circumference, cm

Data from ClinicalTrials.gov

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Genetic Information as a Life Style Change Motivator

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes