The Effect of Unfavorable Histological Features on the Oncological Outcomes of Colon Cancer

Peking Union Medical College Hospital1,367 enrolled

Overview

To explore the effect of unfavorable histological features on the clinical outcomes of patients receiving radical resection of colon cancer.

Study Type

OBSERVATIONAL

Enrollment

1,367

Conditions

Colon Cancer

Interventions

Radical resection of colon cancerPROCEDURE

The patients with colon cancer will receive radical surgery. Adjuvant chemotherapy will be given according to the results of postoperative histological results.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 18-100 years old; 2. Postoperative pathology confirmed colon adenocarcinoma; 3. The tumor is located from the cecum to the sigmoid colon; 4. No distant organ metastasis; Exclusion Criteria: 1. Simultaneous or metachronous multiple primary colorectal cancer; 2. History of previous malignant tumors (except for completely cured cervical carcinoma in situ or basal cell carcinoma or squamous epithelial skin cancer) 3. local excision procedure; 4. palliative resection (R2 resection); 5. pregnant or lactating women.

Outcomes

Primary Outcomes

3-year Disease-free Survival

The time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis, with the most recent recurrence and metastasis.

Time frame: Within 3 years after surgery

Secondary Outcomes

3-year Over-all Survival

The time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis.

Time frame: Within 3 years after surgery

Postoperative complication rate

Time frame: Within 30 days after surgery

Postoperative mortality rate

Time frame: Within 30 days after surgery

Local recurrence rate

Time frame: Within 3 years after surgery

Distant organ metastasis rate

Time frame: Within 3 years after surgery

Data from ClinicalTrials.gov

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