1. to evaluate diagnostic accuracy and performance of IVUS and OCT-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices. 2. to explores the association between intravascular imaging-derived plaque characteristics and invasive physiologic indices.
Given the inherent limitations of coronary angiography to depict the presence of functionally significant epicardial coronary stenosis and discrepancy between angiographic stenosis severity and the presence of myocardial ischemia, invasive physiologic indices such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) has been a standard method to guide decision of revascularization. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are an intracoronary imaging method able to provide information about lumen area, vessel area, plaque burden, and plaque characteristics that can be used for the guidance of revascularization procedure. Several previous studies explored the diagnostic performance of intravascular imaging-defined quantitative parameters to predict functional significance defined by FFR, however, quantitative parameter derived from intravascular imaging showed only moderate diagnostic accuracy and the optimal cut-off value of intravascular imaging-derived minimal lumen area (MLA) or minimal lumen diameter (MLD) were varied according to the patient population, interrogated vessels, and the location of target lesions, suggesting limited clinical relevance of judging functional significance of target stenosis using intravascular imaging alone. Nevertheless, the adoption rate of FFR-guided decision has been limited due to various reasons and intravascular image-guided decision has been still used in substantial proportion of the patients. Recently, new resting pressure-derived indices including resting full-cycle ratio (RFR) or diastolic pressure ratio (dPR) have been introduced as other substitutes for iFR, which does not require administration of hyperemic agents, therefore, possess more convenient in daily practice. Recent study with the largest sample size demonstrated identical diagnostic property and prognostic implication among iFR, RFR, and dPR. As those resting pressure-derived indices might have more generalizability for daily practice, it is expected to raise the adoption rate of physiologic interrogation. Therefore, understanding the association between all the available physiologic indices and intravascular imaging-derived quantitative and qualitative parameters might be important in clinical decision for patient who underwent invasive coronary angiography. In this regard, the investigators sought to evaluate diagnostic accuracy and performance of intravascular imaging-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices and further explores the association between IVUS and OCT-derived plaque characteristics and invasive physiologic indices.
Study Type
OBSERVATIONAL
Enrollment
166
IVUS or OCT measurement in order to evaluate the lesion morphology and stent optimization, and invasive physiologic measurement in order to functional significance of epicardial stenosis
Samsung Medical Center
Seoul, South Korea
RECRUITINGSeoul national university hospital
Seoul, South Korea
RECRUITINGDiagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by fractional flow reserve (FFR)
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by instantaneous wave-free ratio (iFR)
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by diastolic pressure ratio (dPR)
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by resting full-cycle ratio (RFR)
Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR
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Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR
Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR
Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR
Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance assessed by iFR
Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance assessed by dPR
Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR
Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by FFR
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by iFR
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by dPR
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by RFR
Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR
Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by iFR
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by dPR
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR
Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by FFR
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by iFR
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by dPR
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by RFR
Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR
Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR
Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR
Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80
Time frame: During Cardiac Cath
Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by iFR
Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89
Time frame: During Cardiac Cath
Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by dPR
Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89
Time frame: During Cardiac Cath
Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR
Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89
Time frame: During Cardiac Cath
Linear correlation between percent diameter stenosis and FFR
Linear regression analysis between percent diameter stenosis and FFR
Time frame: During Cardiac Cath
Linear correlation between percent diameter stenosis and iFR
Linear regression analysis between percent diameter stenosis and iFR
Time frame: During Cardiac Cath
Linear correlation between percent diameter stenosis and dPR
Linear regression analysis between percent diameter stenosis and dPR
Time frame: During Cardiac Cath
Linear correlation between percent diameter stenosis and RFR
Linear regression analysis between percent diameter stenosis and RFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen diameter and FFR
Linear regression analysis between minimal lumen diameter and FFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen diameter and iFR
Linear regression analysis between minimal lumen diameter and iFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen diameter and dPR
Linear regression analysis between minimal lumen diameter and dPR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen diameter and RFR
Linear regression analysis between minimal lumen diameter and RFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen area and FFR
Linear regression analysis between minimal lumen area and FFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen area and iFR
Linear regression analysis between minimal lumen area and iFR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen area and dPR
Linear regression analysis between minimal lumen area and dPR
Time frame: During Cardiac Cath
Linear correlation between minimal lumen area and RFR
Linear regression analysis between minimal lumen area and RFR
Time frame: During Cardiac Cath
Linear correlation between plaque burden and FFR
Linear regression analysis between plaque burden and FFR
Time frame: During Cardiac Cath
Linear correlation between plaque burden and iFR
Linear regression analysis between plaque burden and iFR
Time frame: During Cardiac Cath
Linear correlation between plaque burden and dPR
Linear regression analysis between plaque burden and dPR
Time frame: During Cardiac Cath
Linear correlation between plaque burden and RFR
Linear regression analysis between plaque burden and RFR
Time frame: During Cardiac Cath
Discriminatory function of percent diameter stenosis to predict functional significance assessed by FFR
Discriminatory function of percent diameter stenosis to predict functional significance defined by FFR≤0.80
Time frame: During Cardiac Cath
Discriminatory function of percent diameter stenosis to predict functional significance assessed by iFR
Discriminatory function of percent diameter stenosis to predict functional significance defined by iFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of percent diameter stenosis to predict functional significance assessed by dPR
Discriminatory function of percent diameter stenosis to predict functional significance defined by dPR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of percent diameter stenosis to predict functional significance assessed by RFR
Discriminatory function of percent diameter stenosis to predict functional significance defined by RFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen diameter to predict functional significance assessed by FFR
Discriminatory function of minimal lumen diameter to predict functional significance defined by FFR≤0.80
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen diameter to predict functional significance assessed by iFR
Discriminatory function of minimal lumen diameter to predict functional significance defined by iFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen diameter to predict functional significance assessed by dPR
Discriminatory function of minimal lumen diameter to predict functional significance defined by dPR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen diameter to predict functional significance assessed by RFR
Discriminatory function of minimal lumen diameter to predict functional significance defined by RFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen area to predict functional significance assessed by FFR
Discriminatory function of minimal lumen area to predict functional significance defined by FFR≤0.80
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen area to predict functional significance assessed by iFR
Discriminatory function of minimal lumen area to predict functional significance defined by iFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen area to predict functional significance assessed by dPR
Discriminatory function of minimal lumen area to predict functional significance defined by dPR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of minimal lumen area to predict functional significance assessed by RFR
Discriminatory function of minimal lumen area to predict functional significance defined by RFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of plaque burden to predict functional significance assessed by FFR
Discriminatory function of plaque burden to predict functional significance defined by FFR≤0.80
Time frame: During Cardiac Cath
Discriminatory function of plaque burden to predict functional significance assessed by iFR
Discriminatory function of plaque burden to predict functional significance defined by iFR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of plaque burden to predict functional significance assessed by dPR
Discriminatory function of plaque burden to predict functional significance defined by dPR≤0.89
Time frame: During Cardiac Cath
Discriminatory function of plaque burden to predict functional significance assessed by RFR
Discriminatory function of plaque burden to predict functional significance defined by RFR≤0.89
Time frame: During Cardiac Cath