This study is a effectiveness study of the application of high-definition enhanced computed-tomography for patients with chronic thromboembolic pulmonary hypertension(CTEPH).The patients with CTEPH was randomized into 2 groups,precise pulmonary endarterectomy group(guided by enhanced CT scanning) and traditional pulmonary endarterectomy group,the hemodynamic changes tested with right sided heart catherization from baseline to post-operative period and end-point including peri-operative deaths,follow-up mortality,follow-up parameters of ultrasonic cardiogram(UCG),right-sided heart catherization(RHC),nuclear magnetic resonance imaging(MRI),cardiac pulmonary exercise test(CPET) are documented,so as to compare the prognosis between these 2 groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
72
For patients in Group 1,precisely analyzed CT scanning and/or pulmonary angiography will be done,and the patients in Group 1 will receive PEA procedure with the guide of precise 3-D imaging techniques
Fuwai Hospital,Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
RECRUITINGChange from Baseline pulmonary systolic pressure within 1 month
Systolic pulmonary pressure result tested by right-sided heart
Time frame: within 1 month before and after pulmonary endarterectomy surgery
Change from Baseline pulmonary mean pressure within 1 month
Mean pulmonary pressure result tested by right-sided heart
Time frame: within 1 month before and after pulmonary endarterectomy surgery
Change from Baseline pulmonary vascular resistance within 1 month
Pulmonary vascular resistance result tested by right-sided heart
Time frame: within 1 month before and after pulmonary endarterectomy surgery
Change from Baseline cardiac output within 1 month
Cardiac output result tested by right-sided heart
Time frame: within 1 month before and after pulmonary endarterectomy surgery
mortality rate after surgery
mortality rate after surgery
Time frame: immediately after the surgery to the longest 48 months follow-up period
Follow-up right ventricular ejection fraction
Assessed by UCG
Time frame: 3-24 months after the surgeries
Follow-up tricuspid annular plane systolic excursion
Assessed by UCG
Time frame: 3-24 months after the surgeries
Follow-up right ventricular anterior-posterior diameter
Assessed by UCG
Time frame: 3-24 months after the surgeries
Follow-up tricuspid insufficiency level
Assessed by UCG
Time frame: 3-24 months after the surgeries
Follow-up peak oxygen consumption (Peak O2) result
Assessed by cardio-pulmonary exercise test (CPET)
Time frame: 6-24 months after the surgeries
Follow-up Peak O2%
Assessed by CPET
Time frame: 6-24 months after the surgeries
Follow-up 6-minutes walking distance
Assessed by CPET
Time frame: 6-24 months after the surgeries
follow-up NYHA classes
NYHA classes in the follow up period,either with telephone follow-up or out-patient follow up
Time frame: 6-24 months after surgeries
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